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During May 2022, a global mpox outbreak was identified. A CDC clinical team began providing consultations§ to U.S. clinicians caring for patients with mpox, developing guidance and other online clinical resources for health care providers, and issuing health alerts, when emerging clinical concerns (e.g., severe infections in patients with advanced HIV infection) were detected. For more information about this paper: Interim Clinical Treatment Considerations for Severe Manifestations of Mpox — United States, February 2023 | MMWR (cdc.gov)